S. BASCO expone en el periodico ABC una utilidad terapeutica de celulas madre: "La creacion de un corazon artificial"
MADRID. Probada hasta la saciedad la capacidad de las células madre, tanto las embrionarias como las adultas y las pluripotentes -o inducidas-, para generar todo tipo de tejidos, la medicina regenerativa cuenta con un arma de inestimable capacidad para reparar diferentes daños. La regeneración de segmentos de vasos sanguíneos, o de pedazos de tejido muscular, o de «parches» de tejido pulmonar, o de «remiendos» cutáneos es ya una realidad médica... pero el santo grial que representaría la regeneración de todo un órgano completo se hallaba aún en el ámbito de la medicina-ficción.
Las células madre pueden lograrlo como ladrillos biológicos que son, pero necesitan un armazón, una estructura sobre la que multiplicarse y desarrollar el tejido, con las características precisas requeridas en cada punto del órgano en cuestión. Se han sucedido los intentos poco o nada satisfactorios a partir de estructuras confeccionadas con distintos tipos de materiales plásticos y de silicona biodegradables, pero nadie daba con la fórmula ideal, con una plantilla perfecta sobre la que construir el órgano.
Pues bien, investigadores del Centro para la Reparación Cardiovascular de la Universidad de Minnesota, en Estados Unidos, parecen haber encontrado la solución más prometedora. Un equipo multidisciplinar dirigido por la doctora Doris Taylor ha logrado desarrollar con animales de laboratorio una nueva técnica que permite generar por completo un corazón bioartificial, y dan a conocer su investigación en la revista «Nature Medicine».
Estructura extracelular
Han partido del órgano cardíaco de un cadáver de rata al que se le han eliminado todas sus células -el proceso ha sido denominado«descelularización»-, conservando únicamente la estructura extracelular. Posteriormente le han inyectado células cardíacas neonatales de otra rata, que han generado tejido de forma tan rápida y asombrosa que al cabo de cuatro días el corazón ha sido capaz de realizar contracciones; y a los ocho días ese órgano «vacío» se bastaba, por medio de estimulación eléctrica, para bombear sangre al 2 por ciento de la capacidad de un corazón adulto. «Cuando percibimos los primeros latidos nos quedamos boquiabiertos», afirma el doctor Harald C. Ott, coautor de la investigación.
La descelularización, clave de este proceso, consiste en extraer todas las células de un órgano, dejando sólo su estructura o matriz extracelular. Se lleva a cabo mediante tres lavados sucesivos del órgano con sustancias que actúan a la manera de «detergentes biológicos». «Es como si a un edificio se le eliminase absolutamente todo, salvo la estructura básica de pilares y vigas sobre la que se sustenta», explica Doris Taylor.
El experimento fue repetido, también con resultados espectaculares, con un corazón de cerdo. Pese a todo, los investigadores insisten en que «se trata sólo de un primer avance experimental» y señalan que se necesitarán aún años para aplicar esta técnica en seres humanos. Una vez que se compruebe la funcionalidad de este método en vivo, con el transplante de un corazón bioartificial a un animal de laboratorio, «el objetivo será entonces desarrollar vasos sanguíneos u órganos completos que se generen mediante las células del propio paciente», dice Taylor.
Si esta prometedora técnica llega a buen puerto, la combinación de medicina regenerativa y transplantes, cuyas técnicas se han perfeccionado desde hace medio siglo, permitirá superar tres problemas de gran trascendencia: el rechazo, la escasez de órganos y el corto tiempo de supervivencia de éstos.
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Thanks mate... just dropped by. Will look for BIKE STN when we get to Seattle. Still in Buenos Airies.
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